In many cases, exercise can be used to treat depression, anxiety, and stress. Scott Douglas, having run for over 110,000 miles in his life, knows this personally, and has also done the research behind why and how running can help. Everyone knows that running builds stronger muscles and a healthier heart; science now shows it also helps develop a healthier brain. For those struggling with depression and anxiety, a consistent running routine can enhance the mental-health benefits of talk therapy, antidepressants, and cognitive behavioral therapy. The key to running’s therapeutic power lies in its lasting physiological effects, inducing changes in brain structure and chemistry that other forms of exercise don’t—including the best mood boost in all of sports, thanks to the body’s release of natural pain-relievers.